![]() ![]() In this way, systems biology helps in the design of experiments that, in turn, lead to better models. The end-use of the modeling technique is metabolic engineering: How does a modification to the genome of an organism-by knocking out a particular gene, for example-affect the organism’s operating state? Models, Palsson emphasizes, can drive discovery: When systems biology models yield predictions that disagree with experiment, one can pinpoint what aspects of the organism have not been properly represented or modeled. July 2006 ISBN 432 Read online, or download in secure PDF format Title: An Introduction to Systems Biology Author: Uri Alon Imprint: Chapman and Hall/CRC. ![]() ![]() The challenge is to enumerate what a physicist would call the phase diagram of a biological network as a function of external constraints such as resource availability and other factors, such as biomass generation, that express what biological systems may have evolved to optimize. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models. Without detailed information on kinetic constants, one can nevertheless make progress by focusing on steady states. Palsson’s goal is to model the rate of reactions and the concentrations of the reactants. Palsson is a founder of systems biology and he presents an accessible account that is structured in three parts: reconstruction of biological networks from data, mathematical aspects of reconstruction, and results of the approach.
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